Assuntos
Humanos , Antibioticoprofilaxia , Antibacterianos/uso terapêutico , Complicações Pós-Operatórias/prevenção & controle , Infecções Comunitárias Adquiridas/tratamento farmacológico , Resistência Microbiana a Medicamentos , Dermatopatias Infecciosas/tratamento farmacológico , Endocardite Bacteriana/tratamento farmacológico , Infecção da Ferida Cirúrgica/prevenção & controle , Infecções Respiratórias/tratamento farmacológico , Infecções Urinárias/tratamento farmacológico , Mucosa Bucal/microbiologia , Trato Gastrointestinal/microbiologiaRESUMO
The authors treated with paromomycin 25 patients, with AIDS and cryptosporidiosis. The drug was given orally in a doses of 500 mg qid, for a period of 14 days. Tolerance was good, with just two cases of mild side-effects. Clinical improvement was obtained in 19 (76 per cent) patients. Parasitological cure, however, occurred only in a low percentage (25 per cent). In some cases where initial success was observed, recrudescence occurred after some weeks or few months, but with retreatment again clinical improvement was obtained. Even if it does not lead to frequent parasite eradication, the good clinical results and tolerance permit us to consider paromomycin one of the few drugs effective for the treatment of cryptosporidial diarrhea in AIDS patients. Studies with maintainance therapy are indicated.